• In addition, based on absolute fracture risk calculation, patients with low bone mass (T-score between -1.0 and -2.5 at the femoral neck, total hip or spine) should be treated when there is a 10-year probability of hip fracture that is > or = to 3% or a 10-year probability of a major osteoporosis-related fracture that is > or = to 20% based on the U.S.-adapted WHO algorithm.