| http://www.w3.org/ns/prov#value | - Enzymes activated or overexpressed and related to drug resistance include, but are not limited to thymidylate synthase, dihydrofolate reductase, tyrosine kinases and multidrug resistant enzyme; and ATP-dependent multidrug resistance associated proteins and, in some diseases including colon and prostate cancer, topoisomerase I. Alternatively, resistance to one drug may confer resistance to other, b
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