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  • In addition a number of naturally occurring compounds including selenite, curcumin, digitoxin, dietary flavonoids and the green-tea constituent EGCG inhibit TOP2 or induce TOP2-DNA complexes in cell culture studies [29,30,31,32,33,34] and it has been suggested that flavonoids and catechins derived from the maternal diet may contribute to in utero MLL translocations underlying neonatal leukemias th
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