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  • Accordingly, the present invention provides compounds of Formula I, In Formula I, A is a MetAP-2 inhibitory core, W is O or NR2, and R1 and R2 are each, independently, hydrogen or alkyl; X is alkylene or substituted alkylene, preferably linear C1-C6-alkylene; n is 0 or 1; R3 and R4 are each, independently, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl or arylalkyl
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