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  • Furthermore, factors such as PGE2 may considerably increase migration, inducing CCR7 expression on the surface of DC. Penetration may be limited to the peripheral zones of lymphoid tissue when the DC are still immature, or may reach the deeper T-cell zones, where a greater number of na??ve T-cells are present, when DC are mature and activated.Surface antigen CCR7, present on the cell membrane of D
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