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Again only R65P and A167V mutants yielded functionalcurrents while the other Kir4.1 mutants failed to yield any functional currents despite theKir5.1 channel co-expression (Table 1).While the previous results indicate the loss of Kir4.1 channel function from variousSeSAME mutations they do not provide insights into whether these mutations affect channelgating or cell surface membrane expression.
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