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As used herein, the phrases ???IFN deficient systems??? or ???IFN-deficient substrates??? refer to systems, e.g., cells, cell lines and animals, such as horses, mice, chickens, turkeys, rabbits, rats, etc., which do not produce IFN or produce low levels of IFN (i.e., a reduction in IFN expression of 5-10%, 10-20%, 20-30%, 30-40%, 40-50%, 50-60%, 60-70%, 70-80%, 80-90% or more when compared to IFN-
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