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In preferred embodiments, the ligand binds to TNF Receptor I with an affinity of 300 nM to 5 pM (ie, 3???10???7 to 5???10???12M) or 300 nM to 1 pM, preferably 50 nM to 20 pM, more preferably 5 nM to 200 pM and most preferably 1 nM to 100 pM, for example 1???10???7 M or less, preferably 1???10???8 M or less, more preferably 1???10???9 M or less, advantageously 1???10???10 M or less and most prefera
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