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isa:307275870
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Thus, one aspect of the present invention is a method for preparing a polymer/protein conjugate comprised of (a) reacting a protein moiety having more than one amino group with a water soluble polymer moiety under reducing alkylation conditions, at a pH suitable to selectively activate the ??-amino group at the amino terminus of said protein moiety so that said water soluble polymer selectively at
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isap:137300572
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isa:307275870