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cted plasma phenylalanine concentration greater than 1200 ??M. In specific embodiments, the patient is an infant, more particularly, an infant having a plasma phenylalanine concentration greater than 1200 ??M. In other embodiments, the patient is pregnant and pregnant patient has a plasma phenylalanine concentration of between about 200 ??M to about 600 ??M. Pregnant patients with a plasma phenyla
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isa:49943909