. "VCAM-1 is a member of the immunoglobulin (Ig) gene superfamily Osborn et al., Cell, 59:1203-1211 (1989); Rice et al., Science, 246:1303-1306 (1989)! that is expressed predominantly in vascular endothelium in response to pro-inflammatory cytokines such as IL-1, TNF??, and IL-4 Osborn et al., Cell, 59:1203-1211 (1989); Rice et al., Science, 246:1303-1306 (1989); Thornhill et al., J. Immunol., 145:86" . . .