. "For controlled release dosage forms, the device designated by the United States Pharmacopeia as apparatus 3, also known as reciprocating cylinders\" or Bio-Dis, stands out, especially for its ability to subject formulations to different pH conditions, thus simulating their passage through the human gastrointestinal tract (Klein, Rudolph, Dressman, 2002; Yu, Wang, Hussain, 2002; Kr??mer, Grady, Gaj" . . .