. . "A further embodiment is a method for reducing the cellular content of NF-??B in a cell, muscle, organ, or subject, including contacting the cell, muscle, organ, or subject with a compound described herein. [0107] Other eukaryotic transcription factors that require proteolytic processing include the general transcription factor TFIIA, herpes simplex virus VP16 accessory protein (host cell factor)," . .