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Gout, one of the oldest known forms of arthritis, is characterized by chronic hyperuricemia (serum urate > 450 ??mol/l or 7.0 mg/dl in men; and > 350 ??mol/l or 6.0 mg/dl in women), recurrent attacks of acute arthritis provoked by the release of monosodium urate crystals into synovial spaces, and eventual development in some patients of urate tophi and chronic tophaceous gouty arthritis.
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