"For example, a calcium channel blocker such as flunarizine or nimodipine may be neuroprotective,1,2 but the secondary effects on the cardiovascular system may lead to hypotension and aggravation of the insult.3,4 Some agents used experimentally have caused hypothermia and it has been the hypothermia rather than the primary effect of the agent on the neuron that has led to apparent neuroprotection." . . . . .