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Ulcers and gastrointestinal bleeding: Long-term use of NSAIDs is also the second most common cause of ulcers and gastrointestinal bleeding.Those at highest risk for bleeding include people over age 60, anyone with a history of ulcers or gastrointestinal bleeding, patients with serious heart conditions, people who abuse alcohol, and those who take medications such as anticoagulants (blood thinners)
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