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isa:334551493
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Particularly preferred protease nexin-1 variants of the invention are variants which have high activity relative to a substrate to which natural PN-1 has little or no activity such as variants which inhibit elastase and, more particularly, which inhibit elastase and have their ability to inhibit elastase enhanced in the presence of heparin and/or heparin-like compounds.
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isap:49003557
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isa:334551493