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Leptin may act as an immunomodulator, inducing the release of cytokines, such as tumor necrosis factor (TNF)-??, interferon (INF)-??, interleukin (IL)-18, and tumor growth factor (TGF)-??1, thus promoting liver steatosis and fibrosis[8].Ghrelin is a peptide that acts as an endogenous ligand of the growth hormone secretatog receptor[14].
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