Overall, the integrated QPPR-PBPK model developed in this study is a potentially useful tool for characterizing and reducing the uncertainty associated with the complete lack of knowledge of ????????int in predicting human pharmacokinetics of inhaled VOCs.AcknowledgmentsFinancial support by Agence Fran??aise de S??curit?? Sanitaire de l???Environnement et du Travail (AFSSET; EST-2007-85) and Natur