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  • Conversely, low levels of regulatory cytokines such as TGF-?? have been associated with acute [20] and severe malaria [21],[22], a relative deficiency in IL-10 was seen in those who succumbed to severe malaria [23], significantly lower ratios of IL-10 to TNF-?? were found in patients with severe malarial anaemia [24],[25], and high ratios of IFN-??, TNF-?? and IL-12 to TGF-?? or IL-10 were associa
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