For example, Ueda et al. [15] used size-exclusion-based enrichment of the peptidome in combination with label-free quantitation by nano-LC-MS/MS for peptidome profiling in lung carcinomas.Body fluids, especially blood serum or plasma, and, in particular cases, (primary) cell culture media, serve as typical and readily available sources for a ???peptidomics-driven??? discovery of novel candidate di