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  • For single M1 lesions in the lung, there is always a question of whether this is M1 disease or multiple primaries.9,10,11,12???15 Without comparing a tissue sample of both lesions, the question usually remains unanswered, and even if identical histology is found, this does not exclude two primaries.16,17 Often, it is impossible to get tissue from the primary and possible metastases or second prima
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