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  • Normal PMNs survive for less than 24 hours in the circulation before undergoing apoptosis, but apoptosis is delayed in PMNs migrating into inflammatory foci.7 This inhibition is mediated through cytokines such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-1??, and IL-8.7 Inhibition of PMN apoptosis and prolongation of PMN survival h
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