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  • However, it is possible that under pathological conditions, such as in atherosclerosis in which endothelial function is impaired, the loss of adrenergically-mediated, endothelium-dependent vasodilation may contribute to hyperreactivity to adrenergic stimulation.Paradoxically, it has been shown by Jones et al. [133] that isolated coronary arterioles do not respond to stimulation with ??-adrenergic
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