s capable of differentiation, or tissues such as cartilage connective tissue, fibrocartilage, tendon, and bone within a support structure, such as multi-layered system, scaffold or collagen matrix or formation of superficial cartilage layer. [0089] ???Superficial cartilage layer??? means an outermost layer of cartilage that forms the layer of squamous-like flattened superficial zone chondrocytes c