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  • Both cell types are increased and activated in the respiratory tracts of patients with AERD [31-33].???The enzyme LTC4 synthase, which mediates the formation of LTC4, is overexpressed by eosinophils and other leukocytes in both nasal and pulmonary tissues of some patients with AERD (figure 1) [31,34].???Abnormal aggregations of platelets and leukocytes (specifically, neutrophils, eosinophils, and
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