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  • For more than 30 years, the dopamine hypothesis has dominated theories of schizophrenia, based initially upon observations that drugs that increase dopamine, such as amphetamine and cocaine, can cause psychosis, whereas antipsychotic drugs that decrease dopamine by blocking dopamine D2 receptors can treat psychosis.1 Overactivity in the mesolimbic dopamine pathway is specifically proposed1,2 as th
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