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  • oplastic lesion formation, and down-regulation of COX-2 and iNOS. Although thedown-regulation of two key genes such as COX-2 and iNOS is likely to be important for thepreventative effects of berries, recent unpublished DNA array data indicate that berriesdown-regulate a large number of other genes in NMBA-treated esophagus that areassociated with multiple cellular processes including apoptosis, an
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