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  • Constitutive expression of ST2 mRNA/proteins was detected in mouse bone marrow cell-derived cultured macrophages and mouse alveolar macrophage cell lines.59, 60 Soluble ST2 expression was increased in macrophages in response to LPS and proinflammatory cytokines such as TNF, IL-1 and IL-6.60-62 IL-33 promoted the expression of LPS receptor components, such as MD2, TLR4, soluble CD14 and MyD88.63 Al
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