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  • ??O???, ???NH??? or ???N(lower alkyl)-; [0049] m is an integer of 0 to 4; and [0050] n is an integer of 2 to 5; [0051] and pharmaceutically acceptable salts thereof. [0052] The compounds of above formula (I) are new, provided that R1 is not amino, R2 and R3 are not hydrogen, R5 is not ???CONH2, and Z is not ???O??? or ???NH??? at the same time when ???Y??? (CH2)m???X???R4 is an unsubstituted alkyl
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