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  • However, this reduction is an unlikely explanation because the CD8+ T cell response disparity in IRF-1-/- mice was far greater than that observed in FoxP3-/- mice, which entirely lack Tregs [63].Figure 7Mechanism of selective expansion of WNV-specific CD8+ T cells in IRF-1-/- mice.Cell-intrinsic and ???extrinsic defects of IRF-1 alter CD8+ T cell expansionTo assess how IRF-1 regulates the rapid ex
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