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  • Preferred conditions for Step 6(b) include when R5 is acyloxy and R1 is phenyl in Compound XVII. Suitable nucleophiles are within the scope of those of the formula HQ. Preferred nucleophiles are nitrogen or oxygen-containing nucleophiles such as water, C1 to C10 alcohols, alkyl amines such as methyl or ethyl amine, and hydrazine or substituted hydrazines.
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