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  • Briefly, binding of wnt proteins to a seven-span-transmembrane receptor frizzled (frz) leads to activation of WNT signaling and stabilization of cytoplasmic beta-catenin which can translocate to the cell membrane or nucleus, by mechanisms including regulation of cytokines, matrix metalloproteases (MMPs), TGF-beta, tumor necrosis factor (TNF)-alpha and HGF [35].
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