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  • Although these numerous cytokines have potential effects on B cell immunoglobulin secretion, our study, along with previous reports, has shown that IL-21 is the most dominant cytokine for the generation of LLPCs (11, 13, 22).In addition to its role in long-term humoral immunity, IL-21 is also an important cytokine for CD8 T cell help during chronic infections.
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