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  • LPS recognition by TLR4 induces the expression of NF-kB and regulates the production of proinflammatory cytokines and chemokines including IL-1, IL-6, and CXCL8 [39, 47???50].The critical role of TLR4 in the development of efficient innate host responses to mycobacteria has been demonstrated in functional studies in mice.
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