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  • Leflunomide is a new drug with a different mechanism of action than other DMARDs such as methotrexate, antimalarial drugs (chloroquine and hydroxychloroquine), sulfasalazine, gold, azathioprine, d-penicillamine, and cyclosporin A. Leflunomide is given in a dosage of 100 mg per day for the first one to three days and 20 to 25 mg per day thereafter.
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