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  • Asthma, COPD, or other respiratory conditions could grow worse. ?? Other drugs may also influence the activity of Secobarbital: ??Alcohol, sleep aids, antihistamines, antidepressants, and other drugs that cause tiredness or sedation may increase the drowsiness caused by Secobarbital. ??Rifampin (Rifadin, Rimactine) may decrease the effects of Secobarbital. ?? Drugs other than those listed here may
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