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  • s can be designed such that the nucleotide corresponding to this position is a base which can bind to more than one nucleotide, referred to herein as a ???universal base.??? For example, under this ???wobble??? pairing, inosine (I) binds to U, C or A; guanine (G) binds to U or C, and uridine (U) binds to U or C. Other examples of universal bases include nitroindoles such as 5-nitroindole or 3-nitr
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