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  • Inhibitors of MAPK-p38, ERK, and JNK inhibited ApoE induction by all these agents except glutamate, which was sensitive only to inhibitors of ERK and JNK.ConclusionConditions of glial activation and hyperexcitation can elevate proinflammatory cytokines, ApoE, glutamate, ??APP, and its secreted fragments.
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