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  • It is essential for cells to control the production and activity of such molecules as reactive oxygen species (ROS) in order to protect the genome and regulate cellular processes such as stress response and apoptosis (Elliott and Volkert, 2004).Global defects of multiple mitochondrial oxidative phosphorylation and energy metabolism in APOE3/4 and APOE4/4 ADIn AD pathogenesis and other neurodegener
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