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  • It has been shown that the elevation of cAMP in inflammatory leukocytes inhibits their activation and the subsequent release of inflammatory mediators, including TNF?? and NF??B. Increased levels of cAMP also leads to the relaxation of airway smooth muscle. [0014] Decreasing TNF?? levels and/or increasing cAMP levels thus constitutes a valuable therapeutic strategy for the treatment of many inflam
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