Standard methods for isolating DNA from a biological sample, detecting alterations in a gene and detecting complex between the MART-1 nucleic acid probe and genomic DNA sequences are provided in manuals such as Sambrook et al., (eds) (1989) ???Molecular Cloning, A Laboratory Mineral???, Cold Spring Harbor Press, Plainview, N.Y. and in Ausubel et al., (eds) (1987) in ???Current Protocols in Molecul