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  • Studies in primates have demonstrated that intracerebroventricular infusion of corticotropin-releasing hormone (CRH) as well as proinflammatory cytokines such as interleukin 1 can decrease luteinizing hormone (LH) secretion.6- 8 Stress-induced (hypothalamic) amenorrhea, as well as exercise-induced amenorrhea and anorexia nervosa, activate the hypothalamic-pituitary-adrenal (HPA) axis, increasing c
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