It has been suggested that in some situations, e.g. malnutrition, surgery, that pneumoccocal vaccination be administered.107 Whether this should be advocated for all CD patients with evidence of hyposplenism is not known, but infections should obviously be treated without delay.FOLLOW-UPTop of pageAbstractINTRODUCTIONEPIDEMIOLOGYGLUTENGENETIC PREDISPOSITIONCLINICAL FEATURES AND DIAGNOSISDIAGNOSTIC