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  • to C12 alkenyl, C1 to C12 alkynyl, C1 to C12 heteroalkyl, C4 to C15 aryl, C4 to C15 heteroaryl, C4 to C15 arylalkyl and C4 to C15 heteroarylalkyl substituent, wherein, when X is NRA, both RA and the corresponding R2 or R4 is not hydrogen, and ii) determining whether said compound inhibits or effects signal transduction activity of said GPCR, wherein a compound that inhibits or effects said activi
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