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  • By responding to cellular stresses, such as DNA damage, hypoxia and cell-cycle aberrations, p53 is activated as a transcription factor. p53 can thus help to promote the repair and survival of damaged cells by inducing cell-cycle arrest, or it can promote the permanent removal of damaged cells by inducing programmed cell death or senescence [2].As the p53 gene is either mutated or deleted in more t
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