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  • Synthesis of bis-phosphoroamidate nucleotide analogs of Formula Id, ##STR19## where L1 and L2 are the same and are an amino acid, dipeptide, tripeptide or oligopeptide (4, 5 or 6 amino acid residues) are prepared by conversion of a nucleotide analog (such as PMEA, HPMPC, HPMPA, PMEG, FPMPA, PMPDAP, 9- 2,3-dideoxy-2,3-didehydro-4-phosphonomethoxy-??-D-erythrofuranosyl!adenine (D4AMPI; reg no. 13217
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