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  • Cytokines, including interleukin 1 (IL-1), tumor necrosis factor ??, and IL-2, are thought to be critical to the development of acute GVHD.55,56 Initial phase 1 and 2 studies56,57 using anti???IL-2 receptor monoclonal antibody and anti???tumor necrosis factor ?? monoclonal antibody have shown promising results in controlling corticosteroid-resistant acute GVHD. An IL-1 receptor antagonist is being
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