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  • Further, when two compounds having exactly the same structure, except for the presence of a triple vs. single bond, e.g. comparing Compound D to Compound E, Compound E which has a propargylic alcohol substituted on C-5 has an IC50=17 nM, while Compound D which has a propanol substituent on C-5 has an IC50=38 mM, a two-fold improvement.
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