Dexamethasone is a corticosteroid commonly used in combination with other chemotherapeutic agents in the treatment of WM. Here we examined the antitumor activity of PRIMA-1met alone and in combination with dexamethasone in WM.Design: Two human WM cell lines, BCWM.1 and MWCL-1, with different p53 status were treated with PRIMA-1met alone or in combination with dexamethasone.